Mutagenicity of Chlorinated Aromatic Hydrocarbons containing Oxygen

Mutagenicity of Chlorinated Aromatic Hydrocarbons containing Oxygen

Mutagenicity of twenty seven chlorinated aromatic hydrocarbons containing oxygen in their molecules were examined using preincubation method employingSalmonella typhimuyiumTA100, TA98, TA104 andEscherichia coliWP2uvrA/pKM101 with and without metabolic activation (S9mix) . Chlorobenzoic acids, chloro...

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Veröffentlicht in:Journal of Environmental Chemistry 1996/12/16, Vol.6(4), pp.533-540
Hauptverfasser: OHKUBO, Tadamichi, GOTO, Sumio, ENDO, Osamu, HAYASHI, Tetsuhito, WATANABE, Etsuo, ENDO, Hideaki
Format: Artikel
Sprache:eng
Schlagworte:
chlorinated aromatic hydrocarbon
Escherichia coli WP2uvrA/pKM101
mutagenicity
Salmonella typhimurium TA104
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Zusammenfassung:Mutagenicity of twenty seven chlorinated aromatic hydrocarbons containing oxygen in their molecules were examined using preincubation method employingSalmonella typhimuyiumTA100, TA98, TA104 andEscherichia coliWP2uvrA/pKM101 with and without metabolic activation (S9mix) . Chlorobenzoic acids, chlorobenzaldehydes, and chlorophenylacetic acids showed no mutagenicity under any conditions. Positive results were given in 13 chloride compounds, e.g., benzoyl chloride, with TA100 (0.8-2.7rev./μg) and TA104 (1.0-3.3rev./μg) with S9mix.
ISSN:0917-2408
1882-5818
DOI:10.5985/jec.6.533