Neurogenesis Hypothesis and Phase 2A Clinical Trials of NA-831 for the Treatment of Alzheimer's Disease

The hippocampus continues to generate new neurons throughout life, a process is known as adult hippocampal neurogenesis (AHN). There was a marked and progressive decline of DCX+ cell numbers in AD patients as compared with neurologically healthy individuals. AHN impairment compromises hippocampal function in AD and MCI. This indicates that reduced AHN causes memory impairments and cognitive deterioration in the disease. It was observed that AHN impairment take place prior to the presence of senile plaques and neurofibrillary tangles (NFTs) in the dentate gyrus. Thus, stimulating inherent AHN could serve as a therapeutic target for improving cognitive function and promoting synaptic resilience.