EFFECTS OF SOLVENT, BASE, AND TEMPERATURE IN THE OPTIMISATION OF A NEW CATALYTIC SYSTEM FOR SONOGASHIRA CROSS-COUPLING USING NCP PINCER PALLADACYCLE

The optimisation of a new catalyst system using NCP pincer palladacycle 1 was investigated using the experimental design technique. NCP pincer palladacycle 1 was previously investigated in Suzuki-Miyaura and Heck-Mizoroki cross-couplings and found to be a highly efficient catalyst precursor. In this study, the effects of the type of base (K 3 PO 4 or DABCO), solvent (DMF or dioxane) and reaction temperature (130 or 150 ºC) in the second step on the reactional yield in Sonogashira cross-coupling were assessed using the two-factor design. The results showed that temperature is statistically significant in relation to the reaction yield.