IN VITRO RADICAL-SCAVENGING ACTIVITY, TOXICITY AGAINST A. salina , AND NMR PROFILES OF EXTRACTS OF LICHENS COLLECTED FROM BRAZIL AND ANTARCTICA
Extracts of six lichen species collected from Brazil and Antarctica were investigated for their potential toxicity and radical-scavenging properties. The composition of the extracts was investigated using TLC and NMR, leading to identification of atranorin (1), along with salazinic (2), barbatic (3)...
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Veröffentlicht in: | Química Nova 2014-01, Vol.37 (6), p.1015-1021 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Extracts of six lichen species collected from Brazil and Antarctica were investigated for their potential toxicity and radical-scavenging properties. The composition of the extracts was investigated using TLC and NMR, leading to identification of atranorin (1), along with salazinic (2), barbatic (3), α-alectoronic (4), α-collatolic (5), cryptochlorophaeic (6), caperatic (7), lobaric (8), and protolichesterinic (9) acids. All acetone extracts were evaluated for their 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability and subjected to Artemia salina bioassay. The free-radical-scavenging activities of each extract (100 µg) ranged from 8.9 ± 0.1% to 38.7 ± 2.5% and the EC50 values ranged from 0.24 ± 2.10 to 3.54 ± 0.28 mg mL-1, while the toxicity of the extracts against A. salina were low (151.0 to >600 µg mL-1). |
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ISSN: | 0100-4042 1678-7064 |
DOI: | 10.5935/0100-4042.20140159 |