2 Cases of successful treatment of primary oral cancer by a combined chemotherapy of UFT and platinum derivatives

The study presents 2 patients with primary oral cancer which were treated successfully with the combined neo-adjuvant chemotherapy of UFT and platinum derivatives. Case 1: The patient was a 77-year-old woman. She had a tumor measuring 29×18mm at the right border of tongue, which was diagnosed as squamous cell carcinoma, T2N0M0, Stage II, and the mode of invasion type was grade II according to the Yamamoto-Kohama's classification. UFT was daily administered at 600mg/day after the biopsy, and carboplatin (300mg/m2) was given intravenously on day 20. After these treatments, the tumor almost disappeared. The excised material was histologically estimated Grade IV according to the Ohboshi-Shimosato's classification. There has been no evidence of recurrence and metastasis during the last 6 months. Case 2: The patient was a 58-year-old man. At the first examination, clinical findings revealed a tumor measuring about 20×15mm on the right retromolar region of mandible. It was diagnosed as squamous cell carcinoma, T2N1M0, Stage III, and the mode of invasion grade I according to the Yamamoto-Kohama's classification. After the biopsy, in addition to daily administration of UFT, cisplatin (60 mg/m2) was twice given on day 14 and day 30 intravenously. After the first administration of cisplatin, the rate of tumor regression was 76%, and after the second administration, the tumor almost disappeared clinically. En bloc excision was performed under the general anesthesia and its histological findings showed Grade II b of chemotherapeutic effect according to the Ohboshi-Shimosato's classification. There has been no evdence of recurrence and metastasis during last 3 months since the operation.