Risk Factors of Ovarian Metastasis from Colorectal Cancer by Using Multivariate Analysis

Introduction: We investigated the risk factors for ovarian metastasis of colorectal cancer and examined the significance of prophylactic oophorectomy. Materials and Methods: 552 women who had undergone a surgical resection for colorectal cancer within the past twenty years were studied. The characteristics of ovarian metastasis and reasons for oophorectomy were examined. Risk factors for ovarian metastasis were identified by multivariate analysis, and the prognosis was investigated.Results: Ovarian metastasis, including recurrence, was found in 26 cases (4.7%). Metastasis was observed in 14 of 38 cases (36.8%) showing morphological abnormalities of the ovary. Metastasis was found in case (8.3%) in which an ovary showing no abnormal morphology was resected because the contralateral ovary showed suspected metastatic findings. A multivariate analysis using a logistic regression method identified the following risk factors as being significantly associated with ovarian metastasis of colorectal cancer: age (p