Correlationships between Liver Function Tests and Morphometric Cytological Parameters in Liver Cirrhosis

Significance of morphometric cytological study using computerized color image analyzer was attempted by comparing conventional liver function tests including indocyanine green clearance test (ICGR15). Multiple biopsies were taken from the noncancerous portion of the liver during hepatectomy in 16 cirrhotic patients with hepatocellular carcinoma. The morphological study of the liver, based on various parameters which are characteristic of liver cirrhosis, such as Ratio of hepatic parenchymal area and Hepatic cells per unit area including Hepatic volume, Hepatic parenchymal volume, Hepatic cell volume and Total hepatic cell volume, was performed. Hepatic volume was calculated by Ct scans of the liver. Total hepatic cells volume was calculated by multiplying these parameters. We compared these morphometric cytological parameters with the levels of ICGR15 and the liver function test (albumin, total bilirubin and prothrombin time). A significant correlation was found between ICGR15 and Ratio of hepatic parenchymal area (r=-0.506, p