High risk HPV rate of detection and the genotyping study used remainder specimen of BD SurePathTM method
Objectives : We investigated the detection rate and genotypes of HR-HPV in endocervical cytology specimens to examine the importance of HR-HPV detection and HR-HPV genotyping in cervical cancer screening.Study Design : The study population was composed of women being followed up by periodic checkups...
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| Veröffentlicht in: | Nippon Rinsho Saibo Gakkai zasshi 2017, Vol.56(6), pp.276-282 |
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| container_title | Nippon Rinsho Saibo Gakkai zasshi |
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| creator | UMEZAWA, Takashi OCHIAI, Kazuhiko YAMADA, Kyosuke OCHIAI, Kazunori OKAMOTO, Aikou ISONISHI, Seiji TSUKUMO, Yoko SAWABE, Motoji IKEGAMI, Masahiro |
| description | Objectives : We investigated the detection rate and genotypes of HR-HPV in endocervical cytology specimens to examine the importance of HR-HPV detection and HR-HPV genotyping in cervical cancer screening.Study Design : The study population was composed of women being followed up by periodic checkups for SIL and those undergoing secondary health examinations ; the women from both subgroups were aged ≥20 years. Cases with ASC-US or more severe abnormalities on BD SurePathTM were subjected to genotyping for HR-HPV and underwent cervical biopsy.Results : Of the 134 subjects examined, 108 (80.6%) were found to be positive for HR-HPV. There were 86 subjects in whom the HR-HPV types could be identified, with types 16, 52 and 58 accounting for ≥10% of cases each, and for 48.8% (42/86) overall. Of the subjects with CIN 2 or more severe lesions, 82.6% (38/46) were found to be positive for any of the HR-HPV types 16, 52 and 58, with this percentage increasing to 95.7% (44/46) when types 18, 31 and 33 were also included. The HR-HPV positive rates in cases with CIN 2 or more and |
| doi_str_mv | 10.5795/jjscc.56.276 |
| format | Article |
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Cases with ASC-US or more severe abnormalities on BD SurePathTM were subjected to genotyping for HR-HPV and underwent cervical biopsy.Results : Of the 134 subjects examined, 108 (80.6%) were found to be positive for HR-HPV. There were 86 subjects in whom the HR-HPV types could be identified, with types 16, 52 and 58 accounting for ≥10% of cases each, and for 48.8% (42/86) overall. Of the subjects with CIN 2 or more severe lesions, 82.6% (38/46) were found to be positive for any of the HR-HPV types 16, 52 and 58, with this percentage increasing to 95.7% (44/46) when types 18, 31 and 33 were also included. The HR-HPV positive rates in cases with CIN 2 or more and<CIN 2 lesions were 92.3% (48/52) and 68.0% (34/54), respectively.Conclusion : HR-HPV types 16, 52, 58, 18, 31 and 33 were common in subjects with CIN 2 or more severe lesions. Therefore, particular care is required in the management of cases where any of these HR-HPV types is identified in the presence of ASC-US or more severe abnormalities.</description><identifier>ISSN: 0387-1193</identifier><identifier>EISSN: 1882-7233</identifier><identifier>DOI: 10.5795/jjscc.56.276</identifier><language>eng ; jpn</language><publisher>The Japanese Society of Clinical Cytology</publisher><subject>BD SurePathTM ; Genotyping ; High-risk human papillomavirus ; Liquid based cytology ; Uterine cervical cytology</subject><ispartof>The Journal of the Japanese Society of Clinical Cytology, 2017, Vol.56(6), pp.276-282</ispartof><rights>2017 The Japanese Society of Clinical Cytology</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c93n-396ff168ee79e3c54684154038c6b4cb299518d98bd4fa9fc7bc839693cc51283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4010,27904,27905,27906</link.rule.ids></links><search><creatorcontrib>UMEZAWA, Takashi</creatorcontrib><creatorcontrib>OCHIAI, Kazuhiko</creatorcontrib><creatorcontrib>YAMADA, Kyosuke</creatorcontrib><creatorcontrib>OCHIAI, Kazunori</creatorcontrib><creatorcontrib>OKAMOTO, Aikou</creatorcontrib><creatorcontrib>ISONISHI, Seiji</creatorcontrib><creatorcontrib>TSUKUMO, Yoko</creatorcontrib><creatorcontrib>SAWABE, Motoji</creatorcontrib><creatorcontrib>IKEGAMI, Masahiro</creatorcontrib><title>High risk HPV rate of detection and the genotyping study used remainder specimen of BD SurePathTM method</title><title>Nippon Rinsho Saibo Gakkai zasshi</title><addtitle>J. Jpn. Soc. Clin. Cytol.</addtitle><description>Objectives : We investigated the detection rate and genotypes of HR-HPV in endocervical cytology specimens to examine the importance of HR-HPV detection and HR-HPV genotyping in cervical cancer screening.Study Design : The study population was composed of women being followed up by periodic checkups for SIL and those undergoing secondary health examinations ; the women from both subgroups were aged ≥20 years. Cases with ASC-US or more severe abnormalities on BD SurePathTM were subjected to genotyping for HR-HPV and underwent cervical biopsy.Results : Of the 134 subjects examined, 108 (80.6%) were found to be positive for HR-HPV. There were 86 subjects in whom the HR-HPV types could be identified, with types 16, 52 and 58 accounting for ≥10% of cases each, and for 48.8% (42/86) overall. Of the subjects with CIN 2 or more severe lesions, 82.6% (38/46) were found to be positive for any of the HR-HPV types 16, 52 and 58, with this percentage increasing to 95.7% (44/46) when types 18, 31 and 33 were also included. The HR-HPV positive rates in cases with CIN 2 or more and<CIN 2 lesions were 92.3% (48/52) and 68.0% (34/54), respectively.Conclusion : HR-HPV types 16, 52, 58, 18, 31 and 33 were common in subjects with CIN 2 or more severe lesions. Therefore, particular care is required in the management of cases where any of these HR-HPV types is identified in the presence of ASC-US or more severe abnormalities.</description><subject>BD SurePathTM</subject><subject>Genotyping</subject><subject>High-risk human papillomavirus</subject><subject>Liquid based cytology</subject><subject>Uterine cervical cytology</subject><issn>0387-1193</issn><issn>1882-7233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpFkMtOwzAQAC0EElXpjQ_wB5ASx7FjnxCUR5GKqETFNXLsTeLSOJXtHvr3pLQqpz3szEo7CN2SdMoKye7X66D1lPFpVvALNCJCZEmRUXqJRikVRUKIpNdoEoKt0owSng7ACLVz27TY2_CD58tv7FUE3NfYQAQdbe-wcgbHFnADro_7rXUNDnFn9ngXwGAPnbLOgMdhC9p24A720zP-2nlYqtiuPnAHse3NDbqq1SbA5DTHaPX6sprNk8Xn2_vscZFoSV1CJa9rwgVAIYFqlnORE5YPD2he5brKpGREGCkqk9dK1rqotBgkSbVmJBN0jO6OZ7XvQ_BQl1tvO-X3JUnLQ6fyr1PJeDl0GvCHI74OUTVwhpWPVm_gH-Yn47zRrfIlOPoL3RVz5w</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>UMEZAWA, Takashi</creator><creator>OCHIAI, Kazuhiko</creator><creator>YAMADA, Kyosuke</creator><creator>OCHIAI, Kazunori</creator><creator>OKAMOTO, Aikou</creator><creator>ISONISHI, Seiji</creator><creator>TSUKUMO, Yoko</creator><creator>SAWABE, Motoji</creator><creator>IKEGAMI, Masahiro</creator><general>The Japanese Society of Clinical Cytology</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2017</creationdate><title>High risk HPV rate of detection and the genotyping study used remainder specimen of BD SurePathTM method</title><author>UMEZAWA, Takashi ; OCHIAI, Kazuhiko ; YAMADA, Kyosuke ; OCHIAI, Kazunori ; OKAMOTO, Aikou ; ISONISHI, Seiji ; TSUKUMO, Yoko ; SAWABE, Motoji ; IKEGAMI, Masahiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c93n-396ff168ee79e3c54684154038c6b4cb299518d98bd4fa9fc7bc839693cc51283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>2017</creationdate><topic>BD SurePathTM</topic><topic>Genotyping</topic><topic>High-risk human papillomavirus</topic><topic>Liquid based cytology</topic><topic>Uterine cervical cytology</topic><toplevel>online_resources</toplevel><creatorcontrib>UMEZAWA, Takashi</creatorcontrib><creatorcontrib>OCHIAI, Kazuhiko</creatorcontrib><creatorcontrib>YAMADA, Kyosuke</creatorcontrib><creatorcontrib>OCHIAI, Kazunori</creatorcontrib><creatorcontrib>OKAMOTO, Aikou</creatorcontrib><creatorcontrib>ISONISHI, Seiji</creatorcontrib><creatorcontrib>TSUKUMO, Yoko</creatorcontrib><creatorcontrib>SAWABE, Motoji</creatorcontrib><creatorcontrib>IKEGAMI, Masahiro</creatorcontrib><collection>CrossRef</collection><jtitle>Nippon Rinsho Saibo Gakkai zasshi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>UMEZAWA, Takashi</au><au>OCHIAI, Kazuhiko</au><au>YAMADA, Kyosuke</au><au>OCHIAI, Kazunori</au><au>OKAMOTO, Aikou</au><au>ISONISHI, Seiji</au><au>TSUKUMO, Yoko</au><au>SAWABE, Motoji</au><au>IKEGAMI, Masahiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High risk HPV rate of detection and the genotyping study used remainder specimen of BD SurePathTM method</atitle><jtitle>Nippon Rinsho Saibo Gakkai zasshi</jtitle><addtitle>J. Jpn. Soc. Clin. Cytol.</addtitle><date>2017</date><risdate>2017</risdate><volume>56</volume><issue>6</issue><spage>276</spage><epage>282</epage><pages>276-282</pages><issn>0387-1193</issn><eissn>1882-7233</eissn><abstract>Objectives : We investigated the detection rate and genotypes of HR-HPV in endocervical cytology specimens to examine the importance of HR-HPV detection and HR-HPV genotyping in cervical cancer screening.Study Design : The study population was composed of women being followed up by periodic checkups for SIL and those undergoing secondary health examinations ; the women from both subgroups were aged ≥20 years. Cases with ASC-US or more severe abnormalities on BD SurePathTM were subjected to genotyping for HR-HPV and underwent cervical biopsy.Results : Of the 134 subjects examined, 108 (80.6%) were found to be positive for HR-HPV. There were 86 subjects in whom the HR-HPV types could be identified, with types 16, 52 and 58 accounting for ≥10% of cases each, and for 48.8% (42/86) overall. Of the subjects with CIN 2 or more severe lesions, 82.6% (38/46) were found to be positive for any of the HR-HPV types 16, 52 and 58, with this percentage increasing to 95.7% (44/46) when types 18, 31 and 33 were also included. The HR-HPV positive rates in cases with CIN 2 or more and<CIN 2 lesions were 92.3% (48/52) and 68.0% (34/54), respectively.Conclusion : HR-HPV types 16, 52, 58, 18, 31 and 33 were common in subjects with CIN 2 or more severe lesions. Therefore, particular care is required in the management of cases where any of these HR-HPV types is identified in the presence of ASC-US or more severe abnormalities.</abstract><pub>The Japanese Society of Clinical Cytology</pub><doi>10.5795/jjscc.56.276</doi><tpages>7</tpages></addata></record> |
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| ispartof | The Journal of the Japanese Society of Clinical Cytology, 2017, Vol.56(6), pp.276-282 |
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| language | eng ; jpn |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | BD SurePathTM Genotyping High-risk human papillomavirus Liquid based cytology Uterine cervical cytology |
| title | High risk HPV rate of detection and the genotyping study used remainder specimen of BD SurePathTM method |
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