Comparison of the positive rate of HSIL or worse and percentage of unsatisfactory specimens between BD SurePathTM and conventional methods

Objective : The purpose of this study was to compare the positive rate of Cervical neoplasm and percentage of unsatisfactory specimens between BD SurePathTM (SP) and conventional methods using split samples.Study Design : Samples were collected using Cervex-Brush® and specimens were prepared using conventional and SP to compare the positive rate of HSIL or worse and percentage of unsatisfactory with biopsy. Approved by the Ethics Committee of Jikei University [22-189 (6366)].Results : Five hundred seventy-two subjects with a mean age of 39.0 years were included in the analysis. The results of the conventional were completely consistent with SP in 80.1% of the subjects. When HSIL was used as the cut-off, the overall results of two methods were consistent in 92.4% and the positive rate of HSIL or worse equivalent between two methods. The results of SP compared with biopsy showed a sensitivity of 85.3%, specificity of 81.7%, PPV of 84.1%, NPV of 83.1% and diagnostic accuracy of 83.6%, which were equivalent to or better than conventional. There was a significant difference in the percentage of unsatisfactory between conventional (5.1%) and SP (0%) (p