A case of clear cell adenocarcinoma in the female urethra

Malignant tumors of the female urethra are reportedly uite rare. We report a case of clear-cell carcinoma in a 42-year-old woman treated by urethrectomy. The tumor was located mainly in the muscular layer and tubulopapillary proliferation was microscopically evident. Hobnail and clear cells were observed histologically in some areas, with similar findings seen in voided urine. Immunohistochemical stains for prostate-specific acid phosphatase and prostatespecific antigen were negative. Tumor cells in this case were similar to those of ovarial clear-cell caricnoma. Further studies are needed, however, to establish the origin ofurethral clear-cell carcinoma.