Cytological and pathological study of 3 cases of carcinosarcoma of the uterine body

Background: Uterine carcinosarcoma is a rare and fatal disease. It is difficult to make a correct cytologic diagnosis before treatment. Case Report: We report the cytologic and pathologic findings in 3 cases of carcinosarcoma. Positive cervical cytology was noted in only 1 case. Positive endometrial smears were seen in all 3 cases. Both epithelial and nonepithelial malignant cells were seen in only 1 case, and epithelial or non-epithelial malignant cells were noted in one case each. Correct cytologic or pathologic diagnosis was made in only 1 of 3 cases before treatment. Imprint smear from the uterine specimen showed both epithelial and non-epithelial malignant cells. Immunohistochemically, conflicting results were obtained in the histopathologic specimen; some of the non-epithelial malignant cells showed positive staining for an epithelial marker. Conclusion: The cytologic diagnosis of carcinosarcoma of the uterine body should be made carefully.