Epidemiological study on correlation between cervical lesions and human papillomavirus infection

Human papilloma virus (HPV) infection and HPV type analysis were done by dot blot DNA hybridization. 1) HPV genome was detected in 22.2%(22/99) of mild dysplasia, in 62.9%(22/35) of moderate dysplasia, in 42.9%(6/14) of severe dysplasia, in 59.2%(45/76) of carcinoma in situ (CIS), in 77.4%(24/31) of invasive squamous cell carcinoma and 45.5%(5/11) of invasive adenocarcinoma, while in 1.4%(3/218) of normal women. 2) HPV 52 b genome was detected in 13.9%(10/72) of the cervical lesions, which were negative for HPV 6, 11, 16, 18, 31, 33 and 35 types by Vira Pap or Viratype kit detection system of HPV. 3) HPV 31/33/35 were detected as highly as HPV 16/18 in the cervical intraepithelial neoplasia (CIN) and cervical carcinomas. 4) HPV 16/18 genomes were also detected in 62.5%(5/8) of the vaginal lesions.