Cytologic and histologic studies of cervical human papilloma virus (HPV) infection

Cytologic and histologic studies were performed on 166 cases of cervical HPV infection, which were cytologically detected by mass-screening of uterine cancer. 1) 77 (46.4%) of cervical HPV infection were encounted in 30th. and 63 (38%) in 40th. The relative frequency figures seemed to be inversely related to the age of the patients. 2) Keratosis was detected in 41 (24.7%) by cytology and in 15 (9%) by histology. 3) Koilocytotic lesions (KL) were histologically shown in 79 (47.6%). KL and neoplasia coexisted in 5 (3%). Pure neoplasia without KL was detected in 24 (14.5%). 4) The histologic patterns of 79 KLs were as follows, flat type 76, endophytic type 3. Of these, 7 presented such marked cytologic atypia that they were reported as atypical condyloma. 5) Endophytic type was supposed to be derived from the cervical glands which were occupied by KL as glandular involvement.