Effect of Food on the Prolonged Activity of L-Keflex

L-Keflex is a sustained-release preparation of cephalexin (CEX). It is composed of non-enteric coated granules and enteric coated ones at the potency ratio of 3 to 7. The effect of food on the prolonged activity of L-Keflex was investigated in six volunteers by a cross-over method. 1000 mg of L-Keflex was orally administered to the volunteers after usual meal or light meal. The followings are the results of the study: In both groups of usual and light meals, L-Keflex level of more than 3.13μg/ml in serum lasted for about 8 hours. However, the serum level pattern in the light meal group was apparently different from that in the usual meal group. The former group showed 2 peaks of serum levels, whereas the latter one gave only a single peak.