Compatibility of Lysozyme Chloride Ointment (REFLAP® Ointment) III

Compatibility tests of lysozyme chloride ointment (Reflap® ointment) with anti-skin ulcer agents, steroidal agents, anti-microbial agents, nonsteroidal anti-inflammatory agents, vitamin agents and disinfectant were carried out. Reflap® ointment was mixed with isodine sugar ointment and U-pasta ® by weight of 1: 1 and 3: 1 and mixed with the other ointments and creams in equal weight. And a day's dose of anti-microbial injections and 5ml disinfectant solution were, respectively, mixed with 30g Reflap ® ointment. The mixtures in polyethylene airtight vessels were stored at room temperature for two months. Changes of appearance (e.g., color, odor and bleeding), pH level and lysozyme activity were studied. It was found that the brown oil phase was slightly separated and lysozyme activity was decreased in the mixture with isodine sugar ointment and U-pasta ® in equal weight. The color of the mixture with minomycin ® injection was changed from slightly yellow to yellowish-brown, but lysozyme activity was not changed. In cases of the mixture with Eulax®, Sahne® ointment and Juvela ® ointment, the significant reductions of lysozyme activity immediately occured. No changes were observed in any of other mixtures.