QTc interval prolongation in asymptomatic HIV – infected patients treated and untreated with antiretroviral therapy

Aim: QTc interval prolongation has been found in HIV-infected patients. There are contradictory reports about the effects of antiretroviral drugs on QT interval duration. The aim of the study was to assess if the prolongation of the QTc interval depends on the antiretroviral treatment and other risk...

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Veröffentlicht in:Postȩpy higieny i medycyny doświadczalnej 2019-05, Vol.73, p.225-231
Hauptverfasser: Siwak, Ewa, Suchacz, Magdalena M., Cielniak, Iwona, Kubicka, Joanna, Pulik, Piotr, Sapuła, Mariusz, Firląg-Burkacka, Ewa
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Sprache:eng
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Zusammenfassung:Aim: QTc interval prolongation has been found in HIV-infected patients. There are contradictory reports about the effects of antiretroviral drugs on QT interval duration. The aim of the study was to assess if the prolongation of the QTc interval depends on the antiretroviral treatment and other risk factors related to HIV infection. Material/Methods: 283 adult HIV-infected patients treated in HIV Outpatient Clinic in Warsaw were enrolled in the prospective, single-centre study. Factors related to ART and HIV infection were collected. Electrocardiograms were performed for each patient and QTc interval duration was measured and corrected using Bazett’s heart rate formula. Results: Prolonged QTc interval was identified in 4.9 % HIV-infected patients (median age 34.5 years, 85% male, 89% HIV RNA
ISSN:0032-5449
1732-2693
DOI:10.5604/01.3001.0013.1938