Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from Aromatic a-Bromoketones, Sodium Azide and Terminal Acetylenes via Cu/Cu(OTf)2-catalyzed Click Reaction under Microwave Irradiation
Reaction of aromatic a-bromoketones, sodium azide and aromatic or aliphatic terminal acetylenes in the presence of Cu/Cu(OTf) following the classical method (aqueous acetonitrile at room temperature) and under microwave irradiation (H O at 85 °C) leads to 1,4-disubstituted 1,2,3-triazoles as the fin...
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Veröffentlicht in: | Zeitschrift für Naturforschung. B, A journal of chemical sciences A journal of chemical sciences, 2013-04, Vol.68 (4), p.391-396 |
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container_title | Zeitschrift für Naturforschung. B, A journal of chemical sciences |
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creator | Fazeli, Azadeh Oskooie, Hossein A. Beheshtiha, Yahya S. Heravi, Majid M. Moghaddam, Firouz Matloubi Foroushani, Behzad Koushki |
description | Reaction of aromatic a-bromoketones, sodium azide and aromatic or aliphatic terminal acetylenes in the presence of Cu/Cu(OTf)
following the classical method (aqueous acetonitrile at room temperature) and under microwave irradiation (H
O at 85 °C) leads to 1,4-disubstituted 1,2,3-triazoles as the final products after simple filtration. |
doi_str_mv | 10.5560/znb.2013-3043 |
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subjects | 1,4-Disubstituted 1,2,3-Triazoles Click Reaction Copper/Copper Triflate Cycloaddition Microwave Irradiation Three-Component Reaction α-Bromoketones |
title | Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from Aromatic a-Bromoketones, Sodium Azide and Terminal Acetylenes via Cu/Cu(OTf)2-catalyzed Click Reaction under Microwave Irradiation |
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