EFFECT OF KETAMINE ADMINISTRATION ON TESTICULAR FUNCTIONS IN ALBINO RATS

Ketamine, a composed mixture of (S)- and (R)-ketamine is used for anesthesia in clinical purpose since 1970. In the present study, effect of Ketamine administration on testicular functions like biochemical, gravimetrical and histological analysis has been studied. Three groups of healthy adult colony breed male albino rats having six rats maintained in each group were used for the experimental studies. The rats of groups II and III were administered Ketamine, intraperitoneally, at the dose level 1 and 3 mg/100 gm body weight respectively daily between 10:00 and 11:00 am for 21 days and group I was maintained as control. After the experimental duration, the rats were sacrificed and studied their gravimetric, biochemical and histological analyses of testis. In the results, testicular weights of the rats of group II and III showed significant reduction, histological, biochemical changes were also observed which marked cytotoxicity and inhibition of testicular functions. Histometric changes of testis diameter and surface epithelial cell height were reduced significantly. Biochemical changes are analogous to the gravimetric results. The protein and cholesterol contents are elevated significantly with the graded dose of Ketamine administration. While, in the gravimetric analysis of accessory organs like epididymis, vas deferens, seminal vesicle and prostate gland weights were decreased significantly due to the administration of Ketamine and exhibited as endocrine disruptive drug.