A REVIEW ON CHALLENGES IN DEVELOPING NASAL SPRAYS

The aim of this review is to provide information regarding significant aspects and challenges in developing of nasal sprays. This article outlined the relevant aspects of nasal anatomy, physiology & biological, physicochemical and pharmaceutical factors that must be considered during formulation development of nasal sprays. Nasal drug delivery system is the most preferable route than other routes of administration as it gives rapid onset of action. It is considered as a convenient and reliable route for local and also for systemic administration of drugs. The main highlights of this review includes types, advantages, disadvantages, mechanisms of drug absorption, factors of nasal drug absorption, formulation, methods of manufacturing and filling of nasal sprays, evaluation, characterization and applications.