RELATIONSHIP BETWEEN 25(OH) D LEVELS AND DYSBIOSIS IN CHILDREN - SYSTEMATIC REVIEW
Objective: We systematically analyzed the relationship between 25(OH)D serum levels and intestinal dysbiosis in children. Methods: The following databases were systematically searched: Pubmed, Embase, Lilacs, Scopus, Ebsco, and Cochrane. Two reviewers independently examined the studies, collected da...
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Veröffentlicht in: | Revista Foco 2023-12, Vol.16 (12), p.e3964 |
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creator | Mori, Bruno Feitosa, Ivan Brito Lima, Luiz Eduardo Rodrigues Autran, Roseanne Gomes Souza, Celsa da Silva Moura Barcellos, José Fernando Marques |
description | Objective: We systematically analyzed the relationship between 25(OH)D serum levels and intestinal dysbiosis in children. Methods: The following databases were systematically searched: Pubmed, Embase, Lilacs, Scopus, Ebsco, and Cochrane. Two reviewers independently examined the studies, collected data, assessed the risk of bias, and ranked the levels of evidence for each outcome in the studies. The pre-specified parameters of interest were 25(OH)D serum levels; sex and intestinal dysbiosis. We only included data from peer-reviewed articles in our analyses. Results: In our primary analysis, there was a positive trend between serum 25(OH)D |
doi_str_mv | 10.54751/revistafoco.v16n12-144 |
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Methods: The following databases were systematically searched: Pubmed, Embase, Lilacs, Scopus, Ebsco, and Cochrane. Two reviewers independently examined the studies, collected data, assessed the risk of bias, and ranked the levels of evidence for each outcome in the studies. The pre-specified parameters of interest were 25(OH)D serum levels; sex and intestinal dysbiosis. We only included data from peer-reviewed articles in our analyses. Results: In our primary analysis, there was a positive trend between serum 25(OH)D <20 ng/ml and intestinal dysbiosis, this result should be interpreted with caution. In this systematic review, we identified two observational studies (n=330) with poor quality evidence in which insufficient serum levels of 25(OH)D showed a direct relationship with the occurrence of intestinal dysbiosis, the relationship of intestinal dysbiosis with sufficient levels of Vitamin D is not based on solid evidence. Conclusions: We await the results of ongoing studies to determine this effectiveness.</description><identifier>ISSN: 1981-223X</identifier><identifier>EISSN: 1981-223X</identifier><identifier>DOI: 10.54751/revistafoco.v16n12-144</identifier><language>eng</language><ispartof>Revista Foco, 2023-12, Vol.16 (12), p.e3964</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c974-38e00906216ec5a32b65abe7b5354c18ffe32a51ddead9a249d6ffde84e31e033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Mori, Bruno</creatorcontrib><creatorcontrib>Feitosa, Ivan Brito</creatorcontrib><creatorcontrib>Lima, Luiz Eduardo Rodrigues</creatorcontrib><creatorcontrib>Autran, Roseanne Gomes</creatorcontrib><creatorcontrib>Souza, Celsa da Silva Moura</creatorcontrib><creatorcontrib>Barcellos, José Fernando Marques</creatorcontrib><title>RELATIONSHIP BETWEEN 25(OH) D LEVELS AND DYSBIOSIS IN CHILDREN - SYSTEMATIC REVIEW</title><title>Revista Foco</title><description>Objective: We systematically analyzed the relationship between 25(OH)D serum levels and intestinal dysbiosis in children. Methods: The following databases were systematically searched: Pubmed, Embase, Lilacs, Scopus, Ebsco, and Cochrane. Two reviewers independently examined the studies, collected data, assessed the risk of bias, and ranked the levels of evidence for each outcome in the studies. The pre-specified parameters of interest were 25(OH)D serum levels; sex and intestinal dysbiosis. We only included data from peer-reviewed articles in our analyses. Results: In our primary analysis, there was a positive trend between serum 25(OH)D <20 ng/ml and intestinal dysbiosis, this result should be interpreted with caution. In this systematic review, we identified two observational studies (n=330) with poor quality evidence in which insufficient serum levels of 25(OH)D showed a direct relationship with the occurrence of intestinal dysbiosis, the relationship of intestinal dysbiosis with sufficient levels of Vitamin D is not based on solid evidence. 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title | RELATIONSHIP BETWEEN 25(OH) D LEVELS AND DYSBIOSIS IN CHILDREN - SYSTEMATIC REVIEW |
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