Docking Applied to the Study of Inhibitors of c-Met Kinase

Docking Applied to the Study of Inhibitors of c-Met Kinase

Quinoxaline derivatives were studied as inhibitors of c-Met kinase, a receptor associated with high tumor grade and poor prognosis in a number of human cancers. In this paper we used docking methodologies to predict the binding conformation of a set of quinoxalines and to explain the differences of...

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Veröffentlicht in:ISRN Physical Chemistry 2012-12, Vol.2012 (2012), p.1-5
Hauptverfasser: Gavernet, Luciana, Palestro, Pablo Hernan, Bruno Blanch, Luis E.
Format: Artikel
Sprache:eng
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Zusammenfassung:Quinoxaline derivatives were studied as inhibitors of c-Met kinase, a receptor associated with high tumor grade and poor prognosis in a number of human cancers. In this paper we used docking methodologies to predict the binding conformation of a set of quinoxalines and to explain the differences of biological activities previously reported.
ISSN:2090-7753
2090-7761
2090-7761
DOI:10.5402/2012/391897