Los virus como detonante oncogénico

Viruses are intracellular pathogens, which are replicated within a cell, using their own machinery to generate more viral particles. Viral replication can affect normal host cell genes, thereby modulating signaling pathways that control cell proliferation, differentiation, and death; genomic integrity, and immune-mediated recognition. Viruses, known as oncogenic viruses, cause about 20% of human cancers. The phenomenon of a basic viral infection to tumorigenesis is long due to the involvement of several factors, such as immune complications, cellular mutations, and exposure to other cancer agents. Epstein-Barr virus (EBV), Kaposi’s sarcoma-associated with herpes, also known as type-8 Herpes virus (HHV-8), human papillomavirus (HPV), hepatitis B virus (HBV), hepatitis C virus (HCV) and type-1 human T-cell lymphotropic virus (HTLV-1) are involved in the development of humans cancers.