A comparison of haloperidol plasma levels among Japanese, Korean and Swedish psychiatric patients

A comparison of haloperidol plasma levels among Japanese, Korean and Swedish psychiatric patients

Purpose: The purpose of this study is to compare the steady-state plasma levels of HAL between Japanese, Koreans and Swedes who were treated with HAL monotherapy per os. Method: The steady-state plasma levels of haloperidol (HAL) in 75 Japanese, 120 Korean, and 50 Swedish psychiatric patients treate...

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Veröffentlicht in:Clinical Neuropsychopharmacology and Therapeutics 2010/10/01, Vol.1, pp.24-31
Hauptverfasser: Morita, Sachiyo, Roh, Hyung-Keun, Shimoda, Kazutaka, Someya, Toshiyuki, Shibasaki, Morikazu, Hirokane, Genta, Svensson, Jan-Olof, Bertilsson, Leif
Format: Artikel
Sprache:eng
Schlagworte:
ethnic difference
haloperidol
steady-state plasma concentration
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Zusammenfassung:Purpose: The purpose of this study is to compare the steady-state plasma levels of HAL between Japanese, Koreans and Swedes who were treated with HAL monotherapy per os. Method: The steady-state plasma levels of haloperidol (HAL) in 75 Japanese, 120 Korean, and 50 Swedish psychiatric patients treated orally with HAL were compared. Results: Significantly higher doses of HAL were used in the Koreans (mean dose = 21 mg/day) than in the Japanese (15 mg/day) or Swedes (9 mg/day) (one-way analysis of variance (ANOVA) (p
ISSN:1884-8826
1884-8826
DOI:10.5234/cnpt.1.24