Practical Synthesis of NPY Antagonist Drug Candidates for Treatment of Obesity

Obesity poses a major risk for metabolic diseases like diabetes, hyperlipemia, cardiovascular disease and so on. Endogenous neuropeptide Y (NPY) is mediated by NPY receptors to cause the function which is involved in regulating feeding behavior. Recently, our basic research efforts identified highly potent and orally active NPY receptor antagonists. In this review article, we describe practical syntheses of three drug candidates from process chemistry perspective.