Enantioselective Total Synthesis of Taxusin and Taxol

Aiming at the construction of taxane ABC tricarbocycles, a useful methodology including an aldol-like eight-membered B ring cyclization between dienol silyl ethers and acetals was explored. By applying this methodology, the enantioselective total synthesis of (+) -taxusin and (-) -taxol have been ac...

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Veröffentlicht in:	Journal of Synthetic Organic Chemistry, Japan Japan, 2000/03/01, Vol.58(3), pp.172-182
Hauptverfasser:	Kuwajima, Isao, Kusama, Hiroyuki
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	taxane diterpenoids taxol taxusin total synthesis
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description	Aiming at the construction of taxane ABC tricarbocycles, a useful methodology including an aldol-like eight-membered B ring cyclization between dienol silyl ethers and acetals was explored. By applying this methodology, the enantioselective total synthesis of (+) -taxusin and (-) -taxol have been achieved, starting from the substrate containing a chiral center at each C 1 site, based on AC to ABC strategies.
doi_str_mv	10.5059/yukigoseikyokaishi.58.172
format	Article
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language	eng ; jpn
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source	EZB-FREE-00999 freely available EZB journals
subjects	taxane diterpenoids taxol taxusin total synthesis
title	Enantioselective Total Synthesis of Taxusin and Taxol
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