Enantioselective Total Synthesis of Taxusin and Taxol

Enantioselective Total Synthesis of Taxusin and Taxol

Aiming at the construction of taxane ABC tricarbocycles, a useful methodology including an aldol-like eight-membered B ring cyclization between dienol silyl ethers and acetals was explored. By applying this methodology, the enantioselective total synthesis of (+) -taxusin and (-) -taxol have been ac...

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Veröffentlicht in:Journal of Synthetic Organic Chemistry, Japan Japan, 2000/03/01, Vol.58(3), pp.172-182
Hauptverfasser: Kuwajima, Isao, Kusama, Hiroyuki
Format: Artikel
Sprache:eng ; jpn
Schlagworte:
taxane diterpenoids
taxol
taxusin
total synthesis
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Zusammenfassung:Aiming at the construction of taxane ABC tricarbocycles, a useful methodology including an aldol-like eight-membered B ring cyclization between dienol silyl ethers and acetals was explored. By applying this methodology, the enantioselective total synthesis of (+) -taxusin and (-) -taxol have been achieved, starting from the substrate containing a chiral center at each C 1 site, based on AC to ABC strategies.
ISSN:0037-9980
1883-6526
DOI:10.5059/yukigoseikyokaishi.58.172