Ossification with Extensive Calcification of Uterine Leiomyoma in a Postmenopausal Woman

Ossification in uterine leiomyomas is extremely rare. Very few cases of ossification and such extensive calcification in leiomyoma have been reported earlier in the literature. Most of the leiomyomas in uterus are known to regress after menopause. Ossification as a secondary change is generally present in the long standing leiomyomas with other degenerative changes like hyalinization and calcification. Most of these changes result from inadequate blood supply. We report a case of an incidental large leiomyoma showing extensive calcification and ossification, which is very rare, occurring in a postmenopausal woman, who died due to organophosphorus poisoning, found at autopsy. This could be an incidental finding probably because of lack of any relevant symptoms and patient's ignorance about the presence of the lesion when alive. This case is reported in view of its rarity. The pathogenesis is also discussed.