Formulation and Evaluation of Microspheres of Diltiazem Hydrochloride by Spray Drying Technique

Microencapsulation technology is an innovator in the encapsulation science. This technology forms a basis for the development of various micro and nano drug loaded capsules. Spray drying is defined as the transformation of a feed from a fluid state (solution, dispersion, or paste) into a dried particulate form by spraying the feed into a hot gaseous dry in medium. In the present study Diltiazem Hydrochloride was used as drug and there was usage of some natural and synthetic polymers were used like Guargum, Xanthan gum, Eudragit L100, Eudragit S100, HPMC K4M. The optimized batch was of polymer Eudragit L100which is a synthetic polymer which shows controlled release tendency for any drug delivery system. In this formulation batch F6 having Eudragit L100as polymer in the concentration of 1:2 ratio by using isopropyl alcohol as solvent gives maximum drug release for 12hrs. as 100.44 % and gives controlled release for 12 hrs. which is better than other batches. Where other polymers like HPMC K4 M, Guargum, Xanthan gum and Eudragit S100was unable to give controlled release. All the prepared formulations show drug content uniformity in the range of 60-70%, the optimized batch show drug content uniformity 70% and follows zero order kinetics.