Acetylcholinesterase Inhibitory and Cytotoxic Activity of Extracts and Isolated Compounds from Strobilanthes ciliatus Nees

Strobilanthes ciliatus was used in the traditional medicine to treat central nervous system problems and cancer. This study aims to investigate the cytotoxic and inhibitory activity of acetylcholinesterase in extracts and isolated compounds of S. ciliatus. Chemical investigation of S. ciliatus led to isolation of two compounds. The isolated compounds were characterized by spectral studies like (IR, UV-Vis, MS and NMR) as lupeol and stigmasterol. The extracts and isolated compound have been evaluated for AChE inhibitory activity by Ellman’s method and cytotoxicity on Hela and K562 cell lines by MTT method. The extracts and the isolated compounds showed moderate activities against acetylecholinesterase enzyme and HeLa and K562 cell lines.