Comparison of Haemodynamic Parameters in Patients on Calcium Channel Blockers and Beta Blockers Undergoing Subarachnoid Block

In lower extremity surgery, a subarachnoid block (SAB) is a regularly used anaesthetic method. SAB is most commonly related with hypotension, with hypertensive patients having a higher frequency. There is insufficient evidence on the effects of antihypertensive drugs such as calcium channel blockers...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International journal of pharmaceutical sciences review and research 2022-08, p.174-179
Hauptverfasser: Prasad, Dr Ashish Prakash, Prakash, Dr Gyan, Dubey, Dr Sweta, Kamendu, Dr Abhishek, Kumar, Dr Hirday
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:In lower extremity surgery, a subarachnoid block (SAB) is a regularly used anaesthetic method. SAB is most commonly related with hypotension, with hypertensive patients having a higher frequency. There is insufficient evidence on the effects of antihypertensive drugs such as calcium channel blockers and beta blockers on hemodynamic measures following subarachnoid block. The question of which antihypertensive drug should be stopped prior to surgery and which can be continued post-operatively is always a conundrum. The aim of the study is to profile Pulse rate, Systolic Blood Pressure, Diastolic Blood Pressure, and Mean Arterial Pressure in Patients on Calcium channel blockers and Beta blockers and to compare the haemodynamic parameters between both the groups. Heart rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Arterial Pressure (MAP) was measured at baseline before the anaesthetic procedure and 3, 6, 9, 15, 30, 45, 60, 75, 90, 105 and 120 minutes after the procedure. Episodes of hypotension during surgery was also recorded. Chi-square test and ANOVA was used in checking significance of difference between outcome parameters of both groups. There was more reduction in heart rate of hypertensive patients on beta blocker therapy as compared to patients on calcium channel blockers and normotensive patients. There was more reduction of systolic, diastolic and mean arterial blood pressure in hypertensive patients as compared to normotensive patients. Hypotension was more frequently observed in patients on Calcium Channel Blocker therapy as compared to patients on beta blocker therapy and normotensive patients. After corelating findings of our study with earlier research, it can be concluded that chances of bradycardia after subarachnoid block is greater in hypertensive patients and patients on beta blocker therapy are at greater risk. From our study, it was found that hypertensive patients on calcium channel blockers were at higher risk of hypotensive episodes. Anaesthetist should be cautious and ready with rescue measures after subarachnoid block on these patients.
ISSN:0976-044X
0976-044X
DOI:10.47583/ijpsrr.2022.v75i02.028