Development and Optimization of Controlled Release Tablet of Ketorolac Using Natural Polymers

The objective of the present work was to develop and optimize ketorolac loaded controlled release tablet using a natural polymer. In this study, we utilized a combination of two natural polymers like Almond gum and guar gum to prepare Ketorolac controlled release tablets. The natural polymers are used in controlled release tablets because has numerous advantages and it is occurs naturally, relatively safe, cheap and do not have any side effects. Ketorolac controlled release tablet were prepared by direct compression method. First Pre-formulation studies were carried out such as FTIR, solubility, bulk and tapped density, housners ratio, Carr’s index, angle of repose etc. Then the tablets were prepared by direct compression using natural polymers. To obtain the desired optimum formulation several formulations had been performed with different excipients and their ratio. For each formulation, post formulation parameters are determined including hardness, weight variation, friability, disintegration and in vitro dissolution, etc. From the test performed it is found that the formulation F3 is best and satisfies all the criteria as controlled release tablet.