Trospium chloride in children: dynamic changes of the residual urine symptom during treatment of urination disorders

Background. A significant place among pediatric urination disorders is occupied by overactive bladder (OAB). Treatment involving the use of M-anticholinergics is aimed to suppress detrusor overactivity. The side effects of treatment include urination problems, incomplete bladder emptying (residual urine), and acute urinary retention. Methods. We monitored 20 children aged 5–15 years, among them 12 boys and 8 girls. The average age (М±δ) was 8.47 ± 3.46 years. The 2-day uroflow monitoring revealed residual urine (RU) in 9 patients (1–15 times per monitoring period). The urination volume and rate, as well as RU, were assessed by uroflow monitoring conducted at home using the SIGMA F uroflowmeter (RZN registration certificate No. 2020/11522 of 5.08.2020). One of the components of combination therapy was trospium chloride (Spasmex) in a dose of 10–15 mg per day, depending on the age and disorder. Statistical data processing was performed using the STATISTICA 10 (StatSoft, Inc., USA) and Excel (Microsoft Office 2016) software packages. The differences were considered significant at p