Makyoyokukanto use in patients with painful afflictions

Aim: Makyoyokukanto (MKYK) is a traditional Japanese medicine used for relieving arthralgia, neuralgia, and myalgia. However, the effectiveness and safety of MKYK remains unclear. In this study, we assessed the effectiveness of MKYK in patients with painful afflictions.Methods: One hundred and sixty-three patients (42 men and 121 women) with painful afflictions were recruited into the study. All participants were treated using non-invasive methods and administered MKYK. The effectiveness of MKYK was assessed following administration by evaluating the need for NSAIDs or other medication. In addition, adverse reactions were monitored.Results: 85.9% of the patients were effectively treated with MKYK. Comorbidities were present in 52.8% of the study participants. The median duration of MKYK treatment was 14 days (2–364 days). The adverse event rate was 1.2%. The adverse events were insomnia caused by Ephedra herb and pseudoaldosteronism by Glycyrrhiza root. All symptoms improved after MKYK withdrawal.Conclusion: The adverse event rate associated with MKYK use was low, and its onset was relatively rapid. This adverse event rate can be further reduced by focusing on the pharmacological action of Ephedra herb and Glycyrrhiza root. This study suggests that MKYK can be used more widely for painful afflictions.