Prophylactic Effect of Cyperus Esculentus Milk on High Dose Acetaminophen Model of Hepatic Toxicity in Wistar Rats

Cyperus esculentus is a wholesome nut with notable nutritional and medicinal benefits. This study investigated the prophylactic impact of Cyperus esculentus milk extract (CE) on high dose acetaminophen (APAP)-induced liver impairment in experimental rats. Thirty rats weighing between 180-200 g were randomly distributed into 6 groups (n=5). Groups 1 (control given only distilled water) and 2 (negative control given APAP) were without treatment, while rats in groups 3, 4, 5 and 6 were orally administered 8.57 mg ascorbic acid, 100 mg/kg, 200 mg/kg and 400 mg/kg of body weight CE respectively for 21 days. On the 22nd day of the experiment, 1 g/kg body weight of acetaminophen was administered orally to rats in groups 2, 3, 4, 5 and 6. The serum and liver of sacrificed animals were collected for analyses. CE at selected doses appreciably prevented high dose acetaminophen-induced increase in serum activities (p