GENES UNDERLYING POSITIVE INFLUENCE OF PRENATAL ENVIRONMENTAL ENRICHMENT AND NEGATIVE INFLUENCE OF PRENATAL EARTHQUAKE SIMULATION AND CORRECTIVE INFLUENCE OF CHINESE HERBALMEDICINE ON RAT OFFSPRING: IRF7 AND NINJ2
Background: Prenatal environmental enrichment (EE) has been proven to positively affect but prenatal stress negatively influence the physiological and psychological processes in animals, whose trans-generational genetic mechanism remains unclearly defined. We aimed to investigate and find out key ge...
Gespeichert in:
| Veröffentlicht in: | African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2014-08, Vol.11 (2), p.367 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 2 |
| container_start_page | 367 |
| container_title | African journal of traditional, complementary, and alternative medicines |
| container_volume | 11 |
| creator | Zhang, Xian Geng Zhang, Hui Lin, Lin Yang, Yi Qing Deng, Ting Ting Liu, Qin Liang, Xiao Li Wang, Mi Qu Peng, De Zhong |
| description | Background: Prenatal environmental enrichment (EE) has been proven to
positively affect but prenatal stress negatively influence the
physiological and psychological processes in animals, whose
trans-generational genetic mechanism remains unclearly defined. We
aimed to investigate and find out key genes underlying the
positive-negative effects derived from prenatal interventions.
Materials and Methods: Pregnant rats were randomized into EE group
(EEG), earthquake simulation group (ESG), herbal group (HG) received
herbal supplements in feed after earthquake simulation, and control
group (CG). Results: Light Box Defecation Test (LBDT) showed EEG
offspring presented less fecal pellets than CG offspring, ESG's
more than CG's, and HG's less than ESG (p's |
| doi_str_mv | 10.4314/ajtcam.v11i2.24 |
| format | Article |
| fullrecord | <record><control><sourceid>bioline_cross</sourceid><recordid>TN_cdi_crossref_primary_10_4314_ajtcam_v11i2_24</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>cria_bioline_tc_tc14059</sourcerecordid><originalsourceid>FETCH-LOGICAL-b210t-6e7d1b6e7c7424f3d816a9cef21a55442e98f41ef1231e742b5355a8a1dd104e3</originalsourceid><addsrcrecordid>eNp9kdFKwzAUhosoOKfX3uYFtuWk6dZ5F7t0jXbpzNqBVyXrUujYnLRD8EF9H7NVRRCEQ07O4f8OP_yOcwu4T12gA705FHrXfwOoSJ_QM6eDwR_3hhiG57_-l85V02wwdn0go47zMeWSL1AmJ1zFz0JO0TxZiFQsORIyjDMuA46SEM0VlyxlMeJyKVQiZ1y2kxJBdBwQkxMk-ZT9xzKVRk8Ze-RoIWZZbLWJPIFBohQP_qJBJKw9jiKu7lk84xMR2AWylGKpFYSLubKm75BQ4ai1IOQDuXYuSr1tzM1X7zpZyNMg6sXJVAQs7q0I4ENvaEZrWNm3GFFCS3ftw1CPC1MS0J5HKTFjv6RgSiAuGKtZea7naV_Deg2YGrfrDNq7Rb1vmtqU-Wtd7XT9ngPOj6nkbSr5KZWcUEv0W2JV7bfVi_kBirrS-ffyUNgCir2x-wmFk4PS</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>GENES UNDERLYING POSITIVE INFLUENCE OF PRENATAL ENVIRONMENTAL ENRICHMENT AND NEGATIVE INFLUENCE OF PRENATAL EARTHQUAKE SIMULATION AND CORRECTIVE INFLUENCE OF CHINESE HERBALMEDICINE ON RAT OFFSPRING: IRF7 AND NINJ2</title><source>Bioline International</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Zhang, Xian Geng ; Zhang, Hui ; Lin, Lin ; Yang, Yi Qing ; Deng, Ting Ting ; Liu, Qin ; Liang, Xiao Li ; Wang, Mi Qu ; Peng, De Zhong</creator><creatorcontrib>Zhang, Xian Geng ; Zhang, Hui ; Lin, Lin ; Yang, Yi Qing ; Deng, Ting Ting ; Liu, Qin ; Liang, Xiao Li ; Wang, Mi Qu ; Peng, De Zhong</creatorcontrib><description>Background: Prenatal environmental enrichment (EE) has been proven to
positively affect but prenatal stress negatively influence the
physiological and psychological processes in animals, whose
trans-generational genetic mechanism remains unclearly defined. We
aimed to investigate and find out key genes underlying the
positive-negative effects derived from prenatal interventions.
Materials and Methods: Pregnant rats were randomized into EE group
(EEG), earthquake simulation group (ESG), herbal group (HG) received
herbal supplements in feed after earthquake simulation, and control
group (CG). Results: Light Box Defecation Test (LBDT) showed EEG
offspring presented less fecal pellets than CG offspring, ESG's
more than CG's, and HG's less than ESG (p's<0.05).
Open-field Test (OFT) score of EEG was higher than CG offspring, of
ESG's was lower than CG's, and HG's higher than
ESG's. Irf7 and Ninj were screened, which were up-regulated in
EEG, down-regulated in ESG (FC<0.5), and were neutralized in HG.
Prenatal EE could positively promote the nervous system development,
prenatal earthquake simulation could retard the nervous system
development and Chinese herbal remedy (JKSQW) which could correct the
retardation. Conclusion: The negative-positive prenatal effect could
contribute to altered gene expression of Irf7 and Ninj2 which also
could play a key role in the improving function of JKSQWfor the
kidneys.</description><identifier>ISSN: 0189-6016</identifier><identifier>EISSN: 0189-6016</identifier><identifier>DOI: 10.4314/ajtcam.v11i2.24</identifier><language>eng</language><publisher>African Ethnomedicines Network</publisher><subject>Earthquake simulation ; Irf7 ; Light Box Defecation Test ; Ninj2 ; Open-field Test ; Prenatal stress</subject><ispartof>African journal of traditional, complementary, and alternative medicines, 2014-08, Vol.11 (2), p.367</ispartof><rights>Copyright 2014 - African Journal of Traditional, Complementary and Alternative Medicines</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b210t-6e7d1b6e7c7424f3d816a9cef21a55442e98f41ef1231e742b5355a8a1dd104e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930,79431</link.rule.ids></links><search><creatorcontrib>Zhang, Xian Geng</creatorcontrib><creatorcontrib>Zhang, Hui</creatorcontrib><creatorcontrib>Lin, Lin</creatorcontrib><creatorcontrib>Yang, Yi Qing</creatorcontrib><creatorcontrib>Deng, Ting Ting</creatorcontrib><creatorcontrib>Liu, Qin</creatorcontrib><creatorcontrib>Liang, Xiao Li</creatorcontrib><creatorcontrib>Wang, Mi Qu</creatorcontrib><creatorcontrib>Peng, De Zhong</creatorcontrib><title>GENES UNDERLYING POSITIVE INFLUENCE OF PRENATAL ENVIRONMENTAL ENRICHMENT AND NEGATIVE INFLUENCE OF PRENATAL EARTHQUAKE SIMULATION AND CORRECTIVE INFLUENCE OF CHINESE HERBALMEDICINE ON RAT OFFSPRING: IRF7 AND NINJ2</title><title>African journal of traditional, complementary, and alternative medicines</title><description>Background: Prenatal environmental enrichment (EE) has been proven to
positively affect but prenatal stress negatively influence the
physiological and psychological processes in animals, whose
trans-generational genetic mechanism remains unclearly defined. We
aimed to investigate and find out key genes underlying the
positive-negative effects derived from prenatal interventions.
Materials and Methods: Pregnant rats were randomized into EE group
(EEG), earthquake simulation group (ESG), herbal group (HG) received
herbal supplements in feed after earthquake simulation, and control
group (CG). Results: Light Box Defecation Test (LBDT) showed EEG
offspring presented less fecal pellets than CG offspring, ESG's
more than CG's, and HG's less than ESG (p's<0.05).
Open-field Test (OFT) score of EEG was higher than CG offspring, of
ESG's was lower than CG's, and HG's higher than
ESG's. Irf7 and Ninj were screened, which were up-regulated in
EEG, down-regulated in ESG (FC<0.5), and were neutralized in HG.
Prenatal EE could positively promote the nervous system development,
prenatal earthquake simulation could retard the nervous system
development and Chinese herbal remedy (JKSQW) which could correct the
retardation. Conclusion: The negative-positive prenatal effect could
contribute to altered gene expression of Irf7 and Ninj2 which also
could play a key role in the improving function of JKSQWfor the
kidneys.</description><subject>Earthquake simulation</subject><subject>Irf7</subject><subject>Light Box Defecation Test</subject><subject>Ninj2</subject><subject>Open-field Test</subject><subject>Prenatal stress</subject><issn>0189-6016</issn><issn>0189-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><recordid>eNp9kdFKwzAUhosoOKfX3uYFtuWk6dZ5F7t0jXbpzNqBVyXrUujYnLRD8EF9H7NVRRCEQ07O4f8OP_yOcwu4T12gA705FHrXfwOoSJ_QM6eDwR_3hhiG57_-l85V02wwdn0go47zMeWSL1AmJ1zFz0JO0TxZiFQsORIyjDMuA46SEM0VlyxlMeJyKVQiZ1y2kxJBdBwQkxMk-ZT9xzKVRk8Ze-RoIWZZbLWJPIFBohQP_qJBJKw9jiKu7lk84xMR2AWylGKpFYSLubKm75BQ4ai1IOQDuXYuSr1tzM1X7zpZyNMg6sXJVAQs7q0I4ENvaEZrWNm3GFFCS3ftw1CPC1MS0J5HKTFjv6RgSiAuGKtZea7naV_Deg2YGrfrDNq7Rb1vmtqU-Wtd7XT9ngPOj6nkbSr5KZWcUEv0W2JV7bfVi_kBirrS-ffyUNgCir2x-wmFk4PS</recordid><startdate>20140814</startdate><enddate>20140814</enddate><creator>Zhang, Xian Geng</creator><creator>Zhang, Hui</creator><creator>Lin, Lin</creator><creator>Yang, Yi Qing</creator><creator>Deng, Ting Ting</creator><creator>Liu, Qin</creator><creator>Liang, Xiao Li</creator><creator>Wang, Mi Qu</creator><creator>Peng, De Zhong</creator><general>African Ethnomedicines Network</general><scope>RBI</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20140814</creationdate><title>GENES UNDERLYING POSITIVE INFLUENCE OF PRENATAL ENVIRONMENTAL ENRICHMENT AND NEGATIVE INFLUENCE OF PRENATAL EARTHQUAKE SIMULATION AND CORRECTIVE INFLUENCE OF CHINESE HERBALMEDICINE ON RAT OFFSPRING: IRF7 AND NINJ2</title><author>Zhang, Xian Geng ; Zhang, Hui ; Lin, Lin ; Yang, Yi Qing ; Deng, Ting Ting ; Liu, Qin ; Liang, Xiao Li ; Wang, Mi Qu ; Peng, De Zhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b210t-6e7d1b6e7c7424f3d816a9cef21a55442e98f41ef1231e742b5355a8a1dd104e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Earthquake simulation</topic><topic>Irf7</topic><topic>Light Box Defecation Test</topic><topic>Ninj2</topic><topic>Open-field Test</topic><topic>Prenatal stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Xian Geng</creatorcontrib><creatorcontrib>Zhang, Hui</creatorcontrib><creatorcontrib>Lin, Lin</creatorcontrib><creatorcontrib>Yang, Yi Qing</creatorcontrib><creatorcontrib>Deng, Ting Ting</creatorcontrib><creatorcontrib>Liu, Qin</creatorcontrib><creatorcontrib>Liang, Xiao Li</creatorcontrib><creatorcontrib>Wang, Mi Qu</creatorcontrib><creatorcontrib>Peng, De Zhong</creatorcontrib><collection>Bioline International</collection><collection>CrossRef</collection><jtitle>African journal of traditional, complementary, and alternative medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Xian Geng</au><au>Zhang, Hui</au><au>Lin, Lin</au><au>Yang, Yi Qing</au><au>Deng, Ting Ting</au><au>Liu, Qin</au><au>Liang, Xiao Li</au><au>Wang, Mi Qu</au><au>Peng, De Zhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GENES UNDERLYING POSITIVE INFLUENCE OF PRENATAL ENVIRONMENTAL ENRICHMENT AND NEGATIVE INFLUENCE OF PRENATAL EARTHQUAKE SIMULATION AND CORRECTIVE INFLUENCE OF CHINESE HERBALMEDICINE ON RAT OFFSPRING: IRF7 AND NINJ2</atitle><jtitle>African journal of traditional, complementary, and alternative medicines</jtitle><date>2014-08-14</date><risdate>2014</risdate><volume>11</volume><issue>2</issue><spage>367</spage><pages>367-</pages><issn>0189-6016</issn><eissn>0189-6016</eissn><abstract>Background: Prenatal environmental enrichment (EE) has been proven to
positively affect but prenatal stress negatively influence the
physiological and psychological processes in animals, whose
trans-generational genetic mechanism remains unclearly defined. We
aimed to investigate and find out key genes underlying the
positive-negative effects derived from prenatal interventions.
Materials and Methods: Pregnant rats were randomized into EE group
(EEG), earthquake simulation group (ESG), herbal group (HG) received
herbal supplements in feed after earthquake simulation, and control
group (CG). Results: Light Box Defecation Test (LBDT) showed EEG
offspring presented less fecal pellets than CG offspring, ESG's
more than CG's, and HG's less than ESG (p's<0.05).
Open-field Test (OFT) score of EEG was higher than CG offspring, of
ESG's was lower than CG's, and HG's higher than
ESG's. Irf7 and Ninj were screened, which were up-regulated in
EEG, down-regulated in ESG (FC<0.5), and were neutralized in HG.
Prenatal EE could positively promote the nervous system development,
prenatal earthquake simulation could retard the nervous system
development and Chinese herbal remedy (JKSQW) which could correct the
retardation. Conclusion: The negative-positive prenatal effect could
contribute to altered gene expression of Irf7 and Ninj2 which also
could play a key role in the improving function of JKSQWfor the
kidneys.</abstract><pub>African Ethnomedicines Network</pub><doi>10.4314/ajtcam.v11i2.24</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0189-6016 |
| ispartof | African journal of traditional, complementary, and alternative medicines, 2014-08, Vol.11 (2), p.367 |
| issn | 0189-6016 0189-6016 |
| language | eng |
| recordid | cdi_crossref_primary_10_4314_ajtcam_v11i2_24 |
| source | Bioline International; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Earthquake simulation Irf7 Light Box Defecation Test Ninj2 Open-field Test Prenatal stress |
| title | GENES UNDERLYING POSITIVE INFLUENCE OF PRENATAL ENVIRONMENTAL ENRICHMENT AND NEGATIVE INFLUENCE OF PRENATAL EARTHQUAKE SIMULATION AND CORRECTIVE INFLUENCE OF CHINESE HERBALMEDICINE ON RAT OFFSPRING: IRF7 AND NINJ2 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T02%3A30%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-bioline_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=GENES%20UNDERLYING%20POSITIVE%20INFLUENCE%20OF%20PRENATAL%20ENVIRONMENTAL%20ENRICHMENT%20AND%20NEGATIVE%20INFLUENCE%20OF%20PRENATAL%20EARTHQUAKE%20SIMULATION%20AND%20CORRECTIVE%20INFLUENCE%20OF%20CHINESE%20HERBALMEDICINE%20ON%20RAT%20OFFSPRING:%20IRF7%20AND%20NINJ2&rft.jtitle=African%20journal%20of%20traditional,%20complementary,%20and%20alternative%20medicines&rft.au=Zhang,%20Xian%20Geng&rft.date=2014-08-14&rft.volume=11&rft.issue=2&rft.spage=367&rft.pages=367-&rft.issn=0189-6016&rft.eissn=0189-6016&rft_id=info:doi/10.4314/ajtcam.v11i2.24&rft_dat=%3Cbioline_cross%3Ecria_bioline_tc_tc14059%3C/bioline_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |