Prédicteurs biologiques de mortalité chez les patients atteints de la Covid-19 : Etude observationnelle de suivi historique monocentrique à Kinshasa: Biological predictors of mortality in patients with Covid-19: observational study of monocentric historical cohort in Kinshasa

Context and objective : Biological prognostic parameters in SARS-CoV-2 viral infection are poorly documented. The aim of the present study was to identify biological predictors of mortality in Congolese Covid-19 patients. Methods: This was a historical follow-up study of Covid-19 patients conducted at Monkole Hospital Center, between April 2020 and December 2021. The endpoint was all-cause mortality. Survival was described by the Kaplan-Meier method. Predictors of mortality were identified using multivariate Cox regression. Results: A total of 477 patients (mean age 55.5 ± 17.2 years, male sex 61%) were included. The mortality rate was 14.3%. Patients who died were significantly older and in respiratory distress. Mean values for N/L ratio, blood urea and creatinine, SGOT, LDH and CRP were significantly higher in patients who died than in those who recovered (p60 years [aHR = 2.75 (1.332 - 5.674); p = 0.006], respiratory distress [HRa = 0.138 (068 - 0.279); p