Interleukin-21 in cancer immunotherapy: Friend or foe?

Interleukin (IL)-21, a cytokine produced by activated conventional CD4+ T lymphocytes and Natural Killer T cells, drives anti-tumor immunity in the skin and kidney. However IL-21 is also pro-inflammatory in many tissues and promotes colitis-associated colon cancer. Understanding the biology of IL-21...

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Veröffentlicht in:	Oncoimmunology 2012-05, Vol.1 (3), p.351-354
Hauptverfasser:	Stolfi, Carmine, Pallone, Francesco, MacDonald, Thomas T., Monteleone, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Biology Bioscience Calcium Cancer Cell colitis-associated colon cancer Cycle IL-17A IL-6 Landes Organogenesis Point of View Proteins STAT3 Tregs
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Beschreibung
Zusammenfassung:	Interleukin (IL)-21, a cytokine produced by activated conventional CD4+ T lymphocytes and Natural Killer T cells, drives anti-tumor immunity in the skin and kidney. However IL-21 is also pro-inflammatory in many tissues and promotes colitis-associated colon cancer. Understanding the biology of IL-21 in these different situations is needed to ensure maximal therapeutic benefit.
ISSN:	2162-4011 2162-402X 2162-402X
DOI:	10.4161/onci.19122