Cleavage of BLM and Sensitivity of Bloom's Syndrome Cells to Hydroxurea
Patients with Bloom's syndrome (BS) show a strong genetic instability and a predisposition to all types of cancer. Here, we report that the Bloom's syndrome protein (BLM) is cleaved in response to hydroxyurea (HU)- or UVC-induced apoptosis. The appearance and solubility of BLM proteolytic...
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Veröffentlicht in: | Cell cycle (Georgetown, Tex.) Tex.), 2002-07, Vol.1 (4), p.268-272 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Patients with Bloom's syndrome (BS) show a strong genetic instability and a predisposition to all types of cancer. Here, we report that the Bloom's syndrome protein (BLM) is cleaved in response to hydroxyurea (HU)- or UVC-induced apoptosis. The appearance and solubility of BLM proteolytic products differed according to whether proteolysis occurred in response to HU or UVC. One BS cell line homozygous for a null mutation in BLM was resistant to both UVC- and HU-induced apoptosis, while another one expressing a mutated BLM protein was resistant to HU-induced apoptosis but displayed normal sensitivity to UVC. Thus, UVC and HU appear to induce apoptosis through distinct pathways.
Key Words:
Bloom's syndrome, Apoptosis, Hydroxyurea, Ultraviolet C radiation, RecQ helicase |
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ISSN: | 1538-4101 1551-4005 |
DOI: | 10.4161/cc.1.4.136 |