Tumor-expressed IL-17D recruits NK cells to reject tumors

Tumor-expressed IL-17D recruits NK cells to reject tumors

Antitumor immunity suppresses tumorigenesis, but we do not understand how transformed cells initiate those immune responses that are essential for effective tumor immunosurveillance. Using the 3-MCA fibrosarcoma model, we identified IL-17D as a tumor-expressed cytokine that recruits natural killer c...

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Veröffentlicht in:Oncoimmunology 2014-12, Vol.3 (12), p.e954853-e954853
Hauptverfasser: Saddawi-Konefka, Robert, O'Sullivan, Timothy, Gross, Emilie T, Washington, Allen, Bui, Jack D
Format: Artikel
Sprache:eng
Schlagworte:
antitumor immunity
Author's View
innate immunity
interleukin 17D
natural killer cells
tumor rejection
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Zusammenfassung:Antitumor immunity suppresses tumorigenesis, but we do not understand how transformed cells initiate those immune responses that are essential for effective tumor immunosurveillance. Using the 3-MCA fibrosarcoma model, we identified IL-17D as a tumor-expressed cytokine that recruits natural killer cells, leading to the polarization of M1 macrophages and tumor rejection.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.4161/21624011.2014.954853