Advancements in practical and scientific bioanalytical approaches to metabolism studies in drug development

Advancement in metabolism profiling approaches and bioanalytical techniques has been revolutionized over the last two decades. Different and approaches along with advanced bioanalytical techniques are enabling the accurate qualitative and quantitative analysis of metabolites. This review summarizes...

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Veröffentlicht in:Bioanalysis 2021-06, Vol.13 (11), p.913-930
Hauptverfasser: Sonawane, Dipali, Reddy, Anuradha, Jadav, Tarang, Sahu, Amit K, Tekade, Rakesh K, Sengupta, Pinaki
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Sprache:eng
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Zusammenfassung:Advancement in metabolism profiling approaches and bioanalytical techniques has been revolutionized over the last two decades. Different and approaches along with advanced bioanalytical techniques are enabling the accurate qualitative and quantitative analysis of metabolites. This review summarizes various modern and approaches for executing metabolism studies with special emphasis on the recent advancement in the field. Advanced bioanalytical techniques, which can be employed in metabolism studies, have been discussed suggesting their particular application based on specific study objectives. This article can efficiently guide the researchers to scientifically plan metabolism studies and their bioanalysis during drug development programs taking advantage of a detailed understanding of instances of failure in the past.
ISSN:1757-6180
1757-6199
DOI:10.4155/bio-2021-0050