An UPLC-MS detection method for the quantification of five antibiotics in human plasma
An UPLC-MS detection method for the quantification of amikacin, flucloxacillin, meropenem, penicillin G and vancomycin was developed and validated. The calibration curves were found to be linear from 0.47 to 50 mg/l for amikacin, 1.28 to 135 mg/l for flucloxacillin, 0.75 to 80 mg/l for meropenem, 0....
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| Veröffentlicht in: | Bioanalysis 2015-09, Vol.7 (18), p.2321-2329 |
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| container_title | Bioanalysis |
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| creator | Chahbouni, Abdel den Dungen, Frank Am van Vos, René M den Burger, Jeroen Cg Sinjewel, Amo Wilhelm, Abraham J Veldkamp, Agnes I Swart, Eleanor L van Weissenbruch, Mirjam M |
| description | An UPLC-MS detection method for the quantification of amikacin, flucloxacillin, meropenem, penicillin G and vancomycin was developed and validated.
The calibration curves were found to be linear from 0.47 to 50 mg/l for amikacin, 1.28 to 135 mg/l for flucloxacillin, 0.75 to 80 mg/l for meropenem, 0.38 to 80 mg/l for penicillin G and 0.73 to 80 mg/l for vancomycin. Between- and within-run accuracy was ranged between 85 and 115%. Between and within imprecision expressed as CV was within 15%.
The validated method was successfully applied to a PK study in very preterm and small for gestational age infants treated for nosocomial sepsis and/or meningitis. |
| doi_str_mv | 10.4155/bio.15.121 |
| format | Article |
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The calibration curves were found to be linear from 0.47 to 50 mg/l for amikacin, 1.28 to 135 mg/l for flucloxacillin, 0.75 to 80 mg/l for meropenem, 0.38 to 80 mg/l for penicillin G and 0.73 to 80 mg/l for vancomycin. Between- and within-run accuracy was ranged between 85 and 115%. Between and within imprecision expressed as CV was within 15%.
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| title | An UPLC-MS detection method for the quantification of five antibiotics in human plasma |
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