Simultaneous determination of levodopa, carbidopa, entacapone, tolcapone, 3-O-methyldopa and dopamine in human plasma by an HPLC-MS/MS method

In this study, we developed and validated a HPLC-MS/MS method capable of simultaneously determining levodopa, carbidopa, entacapone, tolcapone, 3-O-methyldopa and dopamine in human plasma. RESULTS & METHODOLOGY: Chromatographic separation was achieved using a C8 column with a mobile phase consis...

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Veröffentlicht in:	Bioanalysis 2015, Vol.7 (2), p.207-220
Hauptverfasser:	Ribeiro, Rômulo Pereira, Gasparetto, João Cleverson, de Oliveira Vilhena, Raquel, Guimarães de Francisco, Thais Martins, de Francisco, Thais Martins Guimarães, Martins, Cleverson Antônio Ferreira, Cardoso, Marco André, Pontarolo, Roberto, de Carvalho, Katherine Athayde Teixeira
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzophenones - blood Benzophenones - standards Blood Chemical Analysis - methods Carbidopa - blood Carbidopa - standards Catechols - blood Catechols - standards Chromatography, High Pressure Liquid - standards Dihydroxyphenylalanine - analogs & derivatives Dihydroxyphenylalanine - blood Dihydroxyphenylalanine - standards Dopamine - blood Dopamine - standards Humans Levodopa - blood Levodopa - standards Nitriles - blood Nitriles - standards Nitrophenols - blood Nitrophenols - standards Quality Control Reproducibility of Results Tandem Mass Spectrometry - standards Tyrosine - analogs & derivatives
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