Waldenstrom macroglobulinemia with 11q deletion: A rarely diagnosed entity with review of literature

Waldenstrom macroglobulinemia (WM) is a rare, chronic, and indolent B-cell lymphoproliferative disorder characterized by bone marrow infiltration by small lymphocytes, lymphoplasmacytoid cells, and plasma cells along with the presence of a detectable monoclonal immunoglobulin M. It represents 1%–2%...

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Veröffentlicht in:Iraqi Journal of Hematology 2023-07, Vol.12 (2), p.196-200
Hauptverfasser: Giri, Ranjana, Mishra, Pallavi, Mishra, Mouli, Sahu, Nageswar, Bhuyan, Biswajit
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Sprache:eng
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Zusammenfassung:Waldenstrom macroglobulinemia (WM) is a rare, chronic, and indolent B-cell lymphoproliferative disorder characterized by bone marrow infiltration by small lymphocytes, lymphoplasmacytoid cells, and plasma cells along with the presence of a detectable monoclonal immunoglobulin M. It represents 1%–2% of hematological malignancies with an overall incidence of 3–4 cases/million persons/year. Some deletions are associated with a more aggressive IgM gammopathy and have a high probability of symptomatic transformation. 6q deletion, the most common cytogenetic abnormality, which is present in 42% of cases whereas 11q deletion is rare in WM and is present in only 8% of cases. We are presenting a case of a 70-year-old male patient diagnosed as WM with 11q deletion.
ISSN:2072-8069
2543-2702
DOI:10.4103/ijh.ijh_51_23