Bacteriological study of diabetic foot infection in Egypt
Foot infections are one of the major complications of diabetes mellitus and are a significant risk factor for lower extremity amputation. Providing effective antimicrobial therapy is an important component in treating these infections. This study assesses the microbial isolates of patients with diab...
Gespeichert in:
Veröffentlicht in: | Journal of the Arab Society for Medical Research 2013, Vol.8 (1), p.26-32 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Foot infections are one of the major complications of diabetes mellitus and are a
significant risk factor for lower extremity amputation. Providing effective antimicrobial
therapy is an important component in treating these infections. This study assesses the
microbial isolates of patients with diabetic foot infections and their antibiotic
susceptibility pattern.
Patients and methods
A prospective study of 75 patients with diabetic foot infections admitted to Al-Azhar
university hospitals was undertaken. Bacteriological specimens were obtained and
processed using standard hospital procedure for microbiological culture and sensitivity
testing.
Results
Overall, 40 (54%) patients had subcutaneous infections, 22 (29%) had infected
superficial ulcers, seven (9%) had infected deep ulcers involving muscle tissue, and six
(8%) patients had osteomyelitis. A total of 99 pathogens were isolated. Forty percent of
patients had polymicrobial infection, 39 (52%) had single organism infections, and six
(8%) had no growth. Gram-negative bacteria (67%) were more commonly isolated
compared with Gram-positive bacteria (30%). The three most frequently found Grampositive
organisms were Staphylococcus aureus (10.2%), Streptococcus pyogenes
(7.1%) and methicillin-resistant S. aureus (7.1%), and the most common Gram-negative
organisms were Pseudomonas aeruginosa (19.4%), Klebsiella pneumoniae (15.3%),
and Acinetobacter spp. (10.2%). Vancomycin was found to be the most effective against
Gram-positive bacteria, whereas imipenem and amikacin were most effective against
Gram-negative bacteria on antibiotic testing.
Conclusion
Forty percent of diabetic foot infections were polymicrobial. S. aureus and
P. aeruginosa were the most common Gram-positive and Gram-negative organisms,
respectively. This study helps us to choose empirical antibiotics for patients with
diabetic foot infections |
---|---|
ISSN: | 1687-4293 2090-3286 |
DOI: | 10.4103/1687-4293.132774 |