Unexplained cough: pericardial cyst innocent bystander or culprit?

Pericardial cysts are uncommon mediastinal cysts and a rare respiratory cause. Patients are frequently asymptomatic, but cough, dyspnea, and atypical chest discomfort may be present. A 30-year-old female with a three-month history of unexplained wheeze is described. Extensive diagnostic testing and symptomatic treatment for the common causes of cough were ineffectual. Normal results were obtained from bronchoscopy, endoscopy, pulmonary function tests, and otolaryngology evaluation. Chest computed tomography (CT) and magnetic resonance imaging (MRI) revealed a pericardial cyst measuring 5.8 cm in the left cardiophrenic angle. The cyst was removed using video-assisted thorascopic surgery (VATS), and the wheezing resolved completely postoperatively.