Chemical Synthesis of a Highly-Glycosylated Protein: An Example for the Latest Total Chemical Synthesis of O-Glycoproteins
Recent advances in total chemical synthesis of proteins enable us to prepare complex glycoproteins. Herein, the total chemical synthesis of antifreeze glycoprotein, which is a mucin type O-glycoprotein, is introduced as an example of the latest total chemical synthesis of glycoproteins. The function...
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| Veröffentlicht in: | Trends in Glycoscience and Glycotechnology 2019/07/25, Vol.31(181), pp.SE87-SE88 |
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| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | Recent advances in total chemical synthesis of proteins enable us to prepare complex glycoproteins. Herein, the total chemical synthesis of antifreeze glycoprotein, which is a mucin type O-glycoprotein, is introduced as an example of the latest total chemical synthesis of glycoproteins. The functional analysis of the structurally-defined form of the synthetic O-glycoproteins revealed a unique function of O-GalNAcylation of a protein. |
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| ISSN: | 0915-7352 1883-2113 |
| DOI: | 10.4052/tigg.1941.2SE |