Recent Advancements in the Preparation of Structurally Defined Glycoproteins

Chemical or chemoenzymatic synthesis is an emerging approach to produce homogeneous glycoproteins with structurally defined forms. Modern synthetic techniques are capable of the preparation of complex glycoproteins. This minireview especially focuses on the several latest syntheses of N-glycoproteins that generally have relatively large glycan moieties. The structurally defined glycoproteins can be a novel material for understanding molecular basis of glycoprotein functions or the next generation of biopharmaceuticals.