Nephrotoxic Serum Nephritis in C′6-Deficient Rabbits

Rabbits with a hereditary absence of a component activity of complement, C′6, were injected with nephrotoxic sheep serum in amounts which produced only the second phase of nephrotoxic serum nephritis and were found to develop disease of equal severity to that which developed in control animals. Similar results were obtained in defective rabbits which possessed circulating anti-C′6 antibodies or with the use of a γ-globulin fraction of nephrotoxic serum devoid of C′6 activity, thus eliminating the possibility that the results were due to trace amounts of C′6.