Effect of Whole Body X-Irradiation on Induction of Allergic Encephalomyelitis in Rats

Allergic encephalomyelitis (AE) is suppressed in rats given whole body x-irradiation prior to sensitization with spinal cord plus adjuvant. Suppression of the disease is paralleled by reduced production of complement-fixing antibrain antibodies. There is little, if any, suppression of delayed-type i...

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Veröffentlicht in:	The Journal of immunology (1950) 1963-04, Vol.90 (4), p.532-539
Hauptverfasser:	Paterson, Philip Y, Beisaw, Norman E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental Hypersensitivity Radiation Effects - immunology Rats Skin Tests Spinal Cord Tissue Extracts Tuberculin Test
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Zusammenfassung:	Allergic encephalomyelitis (AE) is suppressed in rats given whole body x-irradiation prior to sensitization with spinal cord plus adjuvant. Suppression of the disease is paralleled by reduced production of complement-fixing antibrain antibodies. There is little, if any, suppression of delayed-type immunologic reactivity, based on tuberculin skin testing. X-irradiation after sensitization does not suppress AE. The meaning of these findings with respect to pathogenesis of AE is discussed.
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.90.4.532