Activation of the Alternative (Properdin) Pathway by Divalent Cations

Mg++, Mn++ and Co++ activate the C system as judged by the reduction in cobra venom factor indeed hemolysis, and cleavage of properdin factor B and C3. The maximum effect requires the addition of 5 to 10 mM of these cations to dialyzed sera respond in similar fashion indicating that these divalent c...

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Veröffentlicht in:	The Journal of immunology (1950) 1975-09, Vol.115 (3), p.884-888
Hauptverfasser:	Lew, Frances T, Yukiyama, Yasushi, Waks, Harriet S, Osler, Abraham G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Coagulation Factors - isolation & purification Calcium Carboxymethylcellulose Sodium Cations, Divalent - pharmacology Chromatography, Affinity Chromatography, DEAE-Cellulose Cobalt - pharmacology Complement C3 - metabolism Complement System Proteins - metabolism Dextrans Edetic Acid Egtazic Acid Guinea Pigs Hemolysis - drug effects Humans Immune Sera Immunoelectrophoresis Magnesium - pharmacology Manganese - pharmacology Properdin - metabolism Rabbits - immunology Rats Serum Globulins - analysis Snakes Venoms
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Beschreibung
Zusammenfassung:	Mg++, Mn++ and Co++ activate the C system as judged by the reduction in cobra venom factor indeed hemolysis, and cleavage of properdin factor B and C3. The maximum effect requires the addition of 5 to 10 mM of these cations to dialyzed sera respond in similar fashion indicating that these divalent cations can trigger the alternative pathway without the addition other activating agents.
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.115.3.884